Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients

The aim of this study was to evaluate and compare the effectiveness three different intra-articular injective treatments: hyaluronic acid (HA), autologous conditioned serum (ACS) bone marrow aspirate concentrate (BMAC) for treatment knee osteoarthritis (OA). A Level III retrospective comparative clinical performed on 505 consecutive patients treated with HA (n = 171), ACS 222) or BMAC 112) OA. mean patient age 52 ± 13 years; 54.5% were males. Collected data included demographics, symptoms, visual analogue scale (VAS), Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) radiographic classification grade using plain radiographs advanced imaging. Clinical outcome assessed at 3 12 months post treatment. Significant improvement in VAS WOMAC seen all treatments 3-month follow-up. At months, improved groups, yet only sustained even more severe degenerative changes. This shows that is effective than symptomatic OA, especially